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Regarding suitability of Eppendorf bioprocess equipment in GMP-regulated applications, please reach out to your Eppendorf sales representative.

Microbial Fermentation

Bioreactor control systems for microbial production of proteins, peptides, plasmids, and small molecules

Overview

Bacterial fermentation

Yeast fermentation

A variety of microbes can produce valuable molecules for use in medicine, and the production of chemicals and food. How to best produce plasmids, peptides, small molecules, and amino acids? Your ideas flow. We let them grow. At Eppendorf, we aim to help you bring your microbial fermentation process to the next level. We provide tools for scalable and automated methods to optimize your bioprocesses. The result? More speed, more insights, and success from your processes – all tailored to your specific needs. Let's talk bacterial fermentation , let's talk yeast fermentation . Come talk to us, we are all ears.
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Eppendorf bioreactors for microbial fermentation

Suit the special needs of your organism

The Eppendorf bioreactor systems are designed to support the cultivation of various types of bacteria, yeasts, and other fungi under aerobic, microaerophilic, or anaerobic conditions. They support various gas flow, agitation, and feeding strategies enabling you to develop a process control strategy tailored to your needs.


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Discover our bioprocess controllers

Develop efficient processes faster

Develop efficient processes faster with our orchestrated bioreactor, software, and service solutions, which allow you to combine experimental efficiency with the smart use of data. Our bioprocess solutions support you in increasing speed through parallel processing, automation, and efficient data analysis. Learn how our software solutions leverage artificial intelligence to translate data into strategies that increase product yield and quality.

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Discover our bioprocess development solutions

Save time and mitigate risks

Our single-use bioreactors help you reduce the contamination risk, save setup time, and increase throughput. The Eppendorf bioreactor systems can be equipped with BioBLU® f Single-Use Bioreactors, which are designed specifically for microbial applications. Learn more about how they can significantly reduce the risk of costly and time-consuming batch failures in both research and manufacturing environments.

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Discover BioBLU f Single-Use Bioreactors

Scale your microbial fermentation process

With a more than 100-fold scalability, the Eppendorf fermentor portfolio enables you to develop scale-down models and scale up your bioprocess from R&D to bench-scale production. The standard dimensions of our bioreactors facilitate further scaling up. The Eppendorf bioprocess solutions for commercial manufacturing enable transitioning your bioprocess from R&D to production.

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Discover our glass bioreactors

Microbial fermentation of bacteria and yeasts

Our aim is to empower you on your upstream bioprocess journey and help you elevate your methods to the next level. Whether you work with bacteria or yeast - Let’s talk development, let’s talk optimization.

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Bacterial fermentation

Learn how to get started with bacterial fermentation in bioreactors, how to optimize and scale your fermentation process, and how the Eppendorf bioprocess solutions can support you.
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Yeast fermentation

Learn more about getting started with yeast fermentation in bioreactors, optimizing feeding strategies and protein expression, as well as how the Eppendorf bioprocess solutions can support you.

Take advantage of our application experts' expertise in microbial fermentation

Our application specialists work hands-on in the lab, rigorously testing Eppendorf bioreactors to ensure optimal support for a wide range of microbial fermentation processes. Benefit from their expertise and enhance your own workflows by discovering some of our webinars and application notes below.

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Webinar: From shake flask to bioreactor

Learn the basics of bioreactors and find out how they can help you increase yield and reproducibility. Learn about the basic parts of a bioreactor and how to control culture parameters.
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Application note: Beginner's guide to E. coli fermentation

Learn the differences between batch, fed-batch, and continuous fermentation, as well as how to evaluate the performance of your fermentation process.
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Application note: Pichia pastoris fermentation

Discover a protocol for a methanol-free P. pastoris fermentation workflow in bench-scale bioreactors.
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Webinar: Tailoring oxygen transfer

Learn about advanced strategies to control the dissolved oxygen concentration in the culture medium and to reproduce it at different scales.

How our customers use our products for microbial fermentation

The real experts are our customers. Meet some of them and find out what their work is all about.

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Supporting plants growing in drought and heat

Karner Düngerproduktion focuses on the research and production of plant growth-promoting bacteria (PGPB). They use BioFlo® 120 controllers in product development for fermentation optimization of PGPBs, as well as in the first step of production itself. They serve as seed fermenters for technical production, in which the living bacteria are added to liquid fertilizer applications at the end. The goal is to naturally help plants grow and thrive under adverse environmental conditions such as drought and heat.

Learn more about Karner Düngerproduktion
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Bioproduction success with fermentation scale-up

Earnest Agriculture uses prairie-derived microbes to create probiotic seed coatings to improve crop growth and resilience. In this interview, their CEO talks about the challenges of scaling up fermentation and how the right support can make all the difference.

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Use of BioBLU® Single-Use Bioreactors for pDNA generation and RNA in vitro transcription

Southern RNA is a CDMO specializing in nucleic acid products. In this interview, their COO explains how BioBLU Single-Use Bioreactors can help advancing the RNA industry by increasing turn-around, reducing production downtime, and enhancing scalability.

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Exploring new ways of valorizing agricultural (co)-products

We are using the Eppendorf SciVario® twin equipment to help us in exploring new ways of valorizing our agricultural (co)products through fermentation. We have run bacterial, fungal and yeast-based fermentations on a wide variety of our carbohydrate-rich streams. The versatility of the equipment in terms of configuration, setup and programming options makes it suitable for this type of work.

Hans de Bruijn, Program Manger Fermentation, Cosun Innovation Center

Learn more about Cosun
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Making meat molecules in bioreactors

In this interview, the CEO of Paleo explains how parallel bioreactors help them save time and money when developing precision fermentation processes for the production of meat compounds.

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University of Aarhus: Automation of yeast culture feeding

Researchers at the University of Aarhus used DASware control software to automize yeast culture feeding based on a DO spike. Read, how feed automation saved them time and labour.

Download case study
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University of Brasília and the University of São Paulo: From shaker to bioreactor

Researchers at the University of Brasília and the University of São Paulo transferred a protein production process in E. coli from shake flask to bioreactor. Read, how shake flasks were useful for optimizing a range of process parameters and how bioreactors have enabled a significant increase in productivity.

Download case study
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Praj Industries: Hyaluronic acid production

Scientists at Praj Industries used the BioFlo® 120 bioprocess control station to produce hyaluronic acid in Streptococcus zooepidemicus. Read, how the process was set up, monitored, and controlled using the BioFlo® 120 software.

Download application note
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University of Aachen: Itaconate production

Researchers at the RWTH Aachen produced itaconate in Ustilago maydis. Read, how they easily transferred the production process from the BioFlo® 115 to its successor, the BioFlo® 120.

Download application note
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University of Saarbruecken: Optimization of C. glutamicum cultivation

Researchers at the University of Saarbruecken optimized culture of a metabolically engineered Corynebacterium glutamicum strain in a DASGIP® Parallel Bioreactor system. Read, how the process delivered high titers of the desired chemicals.

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Juelich Research Center: Scale-down model development

Researchers at the Juelich Research Center used a DASGIP® Parallel Bioreactor System to simulate parameter gradients that can occur in the production scale. Read, how the flexible design of both hardware and software allowed a quite uncommon process set-up and enabled process automation.

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Technical University of Vienna: Biomass soft sensor integration

Scientists at the Technical University in Vienna developed a biomass soft sensor based on readily available measurements and process parameters. Read, how they integrated it into the Eppendorf bioprocess environment used it to control various substrate uptake rates.

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